Clear Guidance on the utility of genomics in early breast cancer

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| May 19, 2022

AUA Guidelines

Node-Negative: Chemotherapy Benefit

Updated NCCN Guidelines® from the National Comprehensive Cancer Network® (NCCN®) underscore the unique advantage of the 21-gene (Oncotype DX) test as the only preferred multi-gene test to determine chemotherapy benefit for patients with node-negative early-stage breast cancer. (See page BINV-6 in the Guidelines.)

Node-Positive: Inclusion in the Algorithm

Additionally, the NCCN Guidelines elevated multi-gene assays, including the 21-gene (Oncotype DX) test into the algorithm to consider for assessing prognosis and determining chemotherapy benefit for patients with micrometastases and 1–3 positive nodes. (See page BINV-7 in the Guidelines.)



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NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Breast Cancer Systemic Adjuvant Treatment: Hormone Receptor-Positive, HER2-Negative Disease

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Node-Negative: Chemotherapy Benefit

Read the official press release on the significance of these updated guidelines.

Backed by clinical data

The landmark TAILORx trial results provide definitive answers